Manchester United captain Harry Maguire, forward Mason Greenwood and new signing Edinson Cavani have not travelled for Tuesday’s Champions League group match at Paris St-Germain.
Defender Maguire, 27, scored in Saturday’s 4-1 win at Newcastle, but Greenwood, 19, also missed that game.
Ex-PSG striker Cavani – a deadline-day arrival – has had one training session since a 14-day isolation period ended.
Centre-back Eric Bailly and midfielder Jesse Lingard are also missing.
“We are a little bit depleted but we have more than enough players,” said manager Ole Gunnar Solskjaer, who confirmed midfielder Bruno Fernandes will captain the side in the French capital on Tuesday
“We hope the players won’t be away for too long. Edinson needs a few more days’ training. Maybe we can think about the weekend.
“Hopefully Harry, Eric and Mason as well, but we’re not sure about that.”