Holders Manchester City will travel to Arsenal in the standout tie of the Carabao Cup quarter-final draw.
Joint Premier League leaders Everton welcome Manchester United to Goodison Park, while Tottenham are away to Championship side Stoke City.
Meanwhile, Brentford’s reward for beating Fulham is a home tie against Newcastle United in the club’s first ever League Cup quarter-final.
All quarter-final ties are to be played the week commencing 21 December 2020.
The semi-final ties are then scheduled for 5 and 6 January 2021, with the final of the 2020-21 EFL Cup taking place on 28 February 2021 at Wembley.
The winners of this season’s tournament will not qualify for the Europa League as in the past, but will instead go into the Uefa Europa Conference League, a new European competition.
Quarter final draw
Stoke City v Tottenham
Brentford v Newcastle United
Arsenal v Manchester City
Everton v Manchester United